GSM5718501[Accession] - GEO DataSets

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Items: 4

Select item 2002064501.

TET proteins regulate T cell and iNKT cell lineage specification in a TET2 catalytic dependent manner.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Other; Expression profiling by high throughput sequencing

Platforms:: GPL24247 GPL21103 GPL21273
21 Samples

Download data: BIGWIG, COV, TAB, TXT

Series

Accession:: GSE206450

ID:: 200206450

PubMed Full text in PMC Similar studies

Select item 2001902302.

TET proteins regulate T cell and iNKT cell lineage specification in a TET2 catalytic dependent manner [RNA-Seq]

(Submitter supplied) TET proteins mediate DNA demethylation by oxidizing 5-methylcytosine to 5-hydroxymethylcytosine (5hmC) and other oxidative derivatives. We have previously demonstrated a dynamic enrichment of 5hmC during T and invariant natural killer T cell lineage specification. Here, we investigate shared signatures in gene expression of Tet2/3 DKO CD4 single positive (SP) and iNKT cells in the thymus. We discover that TET proteins exert a fundamental role in regulating the expression of the lineage specifying factor Th-POK, which is encoded by Zbtb7b. more...