GSM5659186[Accession] - GEO DataSets

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Items: 4

Select item 2001867111.

A molecular switch between mammalian MLL complexes dictates response to Menin-MLL inhibition

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL20301 GPL19057 GPL21103
72 Samples

Download data: BW, NARROWPEAK

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Accession:: GSE186711

ID:: 200186711

Select item 2001867092.

A molecular switch between mammalian MLL complexes dictates response to Menin-MLL inhibition [RNA-seq]

(Submitter supplied) The chromatin adaptor Menin interacts with oncogenic fusion proteins encoded by MLL1-rearrangements (MLL1-r), and small molecules that disrupt these associations are currently in clinical trials for the treatment of leukemia. Here, we delineate a molecular switch between the MLL1-Menin and MLL3/4-UTX chromatin modifying complexes that dictates response to Menin-MLL inhibitors. We show that Menin safeguards leukemia cell fitness by impeding binding of the histone demethylase UTX at a subset of non-canonical target gene promoters. more...