GSM5645933[Accession] - GEO DataSets

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Items: 4

Select item 2001863481.

Extensive sex differences in depression-linked variants functionally assayed in mouse brain

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Adeno-associated virus 9; Mus musculus

Type:: Expression profiling by high throughput sequencing; Other

Platforms:: GPL24247 GPL30885
69 Samples

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Accession:: GSE186348

ID:: 200186348

PubMed Full text in PMC Similar studies

Select item 2001863462.

Extensive sex differences in depression-linked variants functionally assayed in mouse brain [Hippocampus]

(Submitter supplied) Here, we selected >1000 variants from over 30 depression-associated loci using brain epigenomic data, and functionally assayed them using in vivo functional assays in the mouse brain to examine sex-by-genotype interactions. We identify extensive sex-by-allele effects in mature hippocampus, suggesting genetic risk and thus disease mechanisms may be distinct between the sexes. Unbiased informatics approaches indicated a role for nuclear hormone receptors, which was supported by . more...