GEO DataSets

(Submitter supplied) The Ten-Eleven Translocation (TET)-mediated DNA modification pathway is intimately involved in transcriptional regulation. As the major catalytic product of TET enzymes, 5-hydroxymethylcytosine (5hmC) is enriched at selected enhancers in a tissue specific manner, with the underlying mechanism yet to be clarified. Here, we report a low complexity insert (LCI) domain within the TET2 catalytic domain that facilitates TET2 condensation and enables its precise chromatin binding, which leads to DNA demethylation at specific genomic regions. more...

Organism:

Mus musculus; Homo sapiens

Type:

Methylation profiling by high throughput sequencing

4 related Platforms

50 Samples

Download data: BW, HIC, TXT