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Items: 4

1.

9sCa: MSL2 is an allelic dosage sensor in mammals

(Submitter supplied) Biallelic expression is important to ensure adequate mRNA levels as well as protect cells from deleterious heterozygous mutations. However, the factors determining biallelic expression at individual gene loci are unknown. Deletion of the MSL complex component MSL2 in hybrid mouse NPCs uncovers an unprecedented function for MSL2 in allelic regulation. While biallelically expressed in wildtype NPCs, a class of MSL2 targets switches from bi to monoallelic expression upon MSL2 loss. The silenced allele loses nascent transcription, accompanied by dramatic changes in local chromatin landscape such as monoallelic gain of H3K27me3 and DNA methylation. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other; Methylation profiling by high throughput sequencing
Platforms:
GPL24247 GPL19057
244 Samples
Download data: BED, BEDPE, BW, RDATA, RDS, TSV, TXT
Series
Accession:
GSE183764
ID:
200183764
2.

MSL2 is an allelic dosage sensor in mammals

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing; Other
4 related Platforms
550 Samples
Download data: BEDPE, TXT
Series
Accession:
GSE183556
ID:
200183556
3.

Illumina NovaSeq 6000 (Mus musculus)

Platform
Accession:
GPL24247
ID:
100024247
4.

9sCa: NPCs_Control_H3-1_rep2

Organism:
Mus musculus
Source name:
Neural progenitor cells
Platform:
GPL24247
Series:
GSE183556 GSE183764
Download data
Sample
Accession:
GSM5570342
ID:
305570342
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Supplemental Content

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