GSM5567497[Accession] - GEO DataSets

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Items: 4

Select item 2001836811.

Epigenetic Remodeling by Vitamin C Potentiates Plasma Cell Differentiation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Other; Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platforms:: GPL24247 GPL24973
37 Samples

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Series

Accession:: GSE183681

ID:: 200183681

PubMed Full text in PMC Similar studies

Select item 2001836802.

Vitamin C Potentiates Plasma Cell Differentiation via TET-mediated DNA modification [RNA-seq]

(Submitter supplied) Ascorbate (vitamin C) is an essential micronutrient in humans. The chronic severe deficiency of ascorbate, termed scurvy, has long been associated with increased susceptibility to infections. How ascorbate affects the immune system at the cellular and molecular levels remained unclear. Here, from a micronutrient screen, we identified ascorbate as a potent enhancer for antibody response by facilitating the IL-21/STAT3-dependent plasma cell differentiation in mouse and human B cells. more...