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Items: 5

1.

Dynamic shifts in occupancy by TAL1 are guided by GATA factors and drive large-scale reprogramming of gene expression during hematopoiesis

(Submitter supplied) We used mouse ENCODE data along with complementary data from other laboratories to study the dynamics of occupancy and the role in gene regulation of the transcription factor TAL1, a critical regulator of hematopoiesis, at multiple stages of hematopoietic differentiation. We combined ChIP-seq and RNA-seq data in six mouse cell types representing a progression from multilineage precursors to differentiated erythroblasts and megakaryocytes. more...
Organism:
Mus musculus
Type:
Other
4 related Platforms
81 Samples
Download data: BEDGRAPH, BIGWIG, BROADPEAK, TXT, WIG
Series
Accession:
GSE51338
ID:
200051338
2.

Divergent functions of hematopoietic transcription factors in lineage priming and differentiation during erythro-megakaryopoiesis

(Submitter supplied) Combinatorial actions of relatively few transcription factors control hematopoietic differentiation. To investigate this process in erythro-megakaryopoiesis, we correlated the genome-wide chromatin occupancy signatures of four master hematopoietic transcription factors (GATA1, GATA2, TAL1, and FLI1) and three diagnostic histone modification marks with the gene expression changes that occur during development of primary cultured megakaryocytes (MEG) and primary erythroblasts (ERY) from murine fetal liver hematopoietic stem/progenitor cells. more...
Organism:
Mus musculus
Type:
Other
Platforms:
GPL13112 GPL9250 GPL6246
42 Samples
Download data: BEDGRAPH, BIGWIG, BROADPEAK, CEL, TXT
Series
Accession:
GSE51337
ID:
200051337
3.

Combinatorial Transcriptional Control in Blood Stem/Progenitor Cells: Genome-wide Analysis of 10 major Transcriptional Regulators

(Submitter supplied) Combinatorial transcription factor (TF) interactions control cellular phenotypes and therefore underpin stem cell formation, maintenance and differentiation. Here we report the genome-wide binding patterns and combinatorial interactions for 10 key regulators of blood stem/progenitor cells (Scl/Tal1, Lyl1, Lmo2, Gata2, Runx1, Meis1, Pu.1, Erg, Fli-1, Gfi1b) thus providing the most comprehensive TF dataset for any adult stem/progenitor cell type to date. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL9250
11 Samples
Download data: BEDGRAPH, TXT
Series
Accession:
GSE22178
ID:
200022178
4.

Illumina Genome Analyzer II (Mus musculus)

Platform
Accession:
GPL9250
ID:
100009250
5.

HPC7_Scl

Organism:
Mus musculus
Source name:
HPC-7 Cell Line
Platform:
GPL9250
Series:
GSE22178 GSE51337 GSE51338
Download data: BEDGRAPH, TXT
Sample
Accession:
GSM552242
ID:
300552242
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Supplemental Content

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