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Items: 4

1.

H3K4 Methylation in β-cells prevents transcriptional downregulation and variance associated with type 2 diabetes.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Drosophila melanogaster
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platforms:
GPL25537 GPL19057
30 Samples
Download data: BW, MTX
Series
Accession:
GSE181951
ID:
200181951
2.

H3K4 Methylation in β-cells prevents transcriptional downregulation and variance associated with type 2 diabetes [RNA-seq]

(Submitter supplied) Insufficient insulin release by β-cells is the primary etiology in type 2 diabetes (T2D) and coincides with impaired expression of genes essential to β-cell function, but drivers of gene expression dysregulation are not well resolved. We find that H3K4me3 peak breadth correlates with gene expression dysregulation in T2D. Using an adult β-cell Dpy30-KO mouse model, we show that global reduction of H3K4 methylation causes downregulation of genes also downregulated in T2D. more...
Organism:
Mus musculus; Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL19057 GPL25537
14 Samples
Download data: CSV, FA, MTX, TXT
Series
Accession:
GSE181950
ID:
200181950
3.

Illumina NextSeq 500 (Drosophila melanogaster; Mus musculus)

Organism:
Drosophila melanogaster; Mus musculus
25 Series
658 Samples
Download data
Platform
Accession:
GPL25537
ID:
100025537
4.

Day 45 RNA-seq WT 1

Organism:
Drosophila melanogaster; Mus musculus
Source name:
Mouse beta cells with S2 cell spike-in
Platform:
GPL25537
Series:
GSE181950 GSE181951
Download data
Sample
Accession:
GSM5514734
ID:
305514734
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Supplemental Content

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