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Items: 4

1.

Cellular identity loss occurring during both iPS cells generation and malignant transformation can be followed using the somatic markers Thy1 and Bcl11b (ATAC-seq)

(Submitter supplied) Coordinated changes of cellular plasticity and cellular identity are critical for pluripotent reprogramming and oncogenic transformation. However, the sequences of cellular/molecular events that orchestrate these intermingled modifications have never been comparatively dissected. Here, we deconvoluted the cellular trajectories of reprogramming (via Oct4/Sox2/Klf4/c-Myc) and transformation (via Ras/c-Myc) at the single-cell resolution and revealed how the two processes intersect prior to bifurcate. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL19057
12 Samples
Download data: BED, NARROWPEAK, TXT
Series
Accession:
GSE181799
ID:
200181799

PubMed Full text in PMC Similar studies SRA Run Selector

2.

The comparative roadmaps of reprogramming and transformation unveiled that cellular plasticity is broadly controlled by Bcl11b and Atoh8

(Submitter supplied) Coordinated changes of cellular plasticity and cellular identity are critical for pluripotent reprogramming and oncogenic transformation. However, the sequences of cellular/molecular events that orchestrate these intermingled modifications have never been comparatively dissected. Here, we deconvoluted the cellular trajectories of reprogramming (via Oct4/Sox2/Klf4/c-Myc) and transformation (via Ras/c-Myc) at the single-cell resolution and revealed how the two processes intersect prior to bifurcate. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
4 related Platforms
59 Samples
Download data: BEDGRAPH, MTX, TSV, TXT, XLS
Series
Accession:
GSE137050
ID:
200137050

PubMed Full text in PMC Similar studies

3.

Illumina NextSeq 500 (Mus musculus)

Organism:
Mus musculus
10486 Series
299248 Samples
Download data
Platform
Accession:
GPL19057
ID:
100019057

4.

T-BLTL (Transforming Intermediate Prone) rep2 (ATAC-seq)

Organism:
Mus musculus
Source name:
mouse embryonic fibroblasts
Platform:
GPL19057
Series:
GSE137050 GSE181799
Download data
Sample
Accession:
GSM5511549
ID:
305511549

SRA Run Selector

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db=gds|term=GSM5511549[Accession]|query=1|qty=2|blobid=MCID_6786de66ebf88d654f79b93f|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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