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Items: 3

1.

EED is required for Mouse Primordial Germ Cell Differentiation in the Embryonic Gonad

(Submitter supplied) Development of Primordial germ cells (PGCs) is required for reproduction. During PGC development in mammals, major epigenetic remodeling occurs which is hypothesized to establish an epigenetic landscape for sex-specific germ cell differentiation and gametogenesis. In order to address the role of Embryonic Ectoderm Development (EED) and Histone 3 lysine 27 trimethylation (H3K27me3) in this process, we created a conditional deletion in EED and show that EED is essential for regulating the timing of sex-specific PGC differentiation in both ovaries and testes, as well as X chromosome dosage decompensation in testes. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing
Platforms:
GPL17021 GPL21103 GPL24247
222 Samples
Download data: CGMAP, TXT
Series
Accession:
GSE139413
ID:
200139413
2.

Illumina NovaSeq 6000 (Mus musculus)

Platform
Accession:
GPL24247
ID:
100024247
3.

scRNA-seq_E12-5_XY_Control_Embryo_2_Rep_6

Organism:
Mus musculus
Source name:
Primordial germ cells
Platform:
GPL24247
Series:
GSE139413
Download data
Sample
Accession:
GSM5505060
ID:
305505060
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db=gds|term=GSM5505060[Accession]|query=1|qty=2|blobid=MCID_6626bb644c13c13a068db2ed|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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