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Items: 4

1.

Transient naive reprogramming corrects hiPS cells functionally and epigenetically [WGBS 2]

(Submitter supplied) Cells undergo a major epigenome reconfiguration when reprogrammed to human induced pluripotent stem cells (hiPS cells). However, the epigenomes of hiPS cells and human embryonic stem (hES) cells differ significantly, which affects hiPS cell function. These differences include epigenetic memory and aberrations that emerge during reprogramming, for which the mechanisms remain unknown. Here we characterized the persistence and emergence of these epigenetic differences by performing genome-wide DNA methylation profiling throughout primed and naive reprogramming of human somatic cells to hiPS cells. more...
Organism:
Homo sapiens
Type:
Methylation profiling by high throughput sequencing
Platforms:
GPL18460 GPL24676 GPL18573
21 Samples
Download data: CGMAP
Series
Accession:
GSE160933
ID:
200160933
2.

Transient naive reprogramming corrects hiPS cells functionally and epigenetically

(Submitter supplied) Cells undergo a major epigenome reconfiguration when reprogrammed to human induced pluripotent stem cells (hiPS cells). However, the epigenomes of hiPS cells and human embryonic stem (hES) cells differ significantly, which affects hiPS cell function. These differences include epigenetic memory and aberrations that emerge during reprogramming, for which the mechanisms remain unknown. Here we characterized the persistence and emergence of these epigenetic differences by performing genome-wide DNA methylation profiling throughout primed and naive reprogramming of human somatic cells to hiPS cells. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
5 related Platforms
110 Samples
Download data: BIGWIG, CGMAP, H5, TAR
Series
Accession:
GSE159297
ID:
200159297
3.

Illumina NextSeq 500 (Homo sapiens)

Platform
Accession:
GPL18573
ID:
100018573
4.

P10_38F_Smith_R

Organism:
Homo sapiens
Source name:
Human pluripotent stem cells
Platform:
GPL18573
Series:
GSE159297 GSE160933
Download data: CGMAP
Sample
Accession:
GSM5412621
ID:
305412621
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