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Items: 4

1.

Hypoxia induces an early primitive streak signature, enhancing spontaneous elongation and lineage representation in gastruloids

(Submitter supplied) The cellular microenvironment together with intrinsic regulators shapes stem cell identity and differentiation capacity. Mammalian early embryos are exposed to hypoxia in vivo and appear to benefit from hypoxic culture in vitro. Yet, how hypoxia influences stem cell transcriptional networks and lineage choices remain poorly understood. Here we investigated the molecular effects of acute and prolonged hypoxia on embryonic and extraembryonic stem cells as well as the functional impact on differentiation potential. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing
Platforms:
GPL24247 GPL21103
27 Samples
Download data: MTX, NARROWPEAK, TSV
Series
Accession:
GSE178628
ID:
200178628

PubMed Full text in PMC Similar studies

2.

Hypoxia induces a transcriptional early primitive streak signature in pluripotent cells enhancing spontaneous elongation and lineage representation in gastruloids [RNA-seq]

(Submitter supplied) The cellular microenvironment together with intrinsic regulators shapes stem cell identity and differentiation capacity. Mammalian early embryos are exposed to hypoxia in vivo and appear to benefit from hypoxic culture in vitro. Yet, how hypoxia influences stem cell transcriptional networks and lineage choices remain poorly understood. Here we investigated the molecular effects of acute and prolonged hypoxia on embryonic and extraembryonic stem cells as well as the functional impact on differentiation potential. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
18 Samples
Download data: TXT
Series
Accession:
GSE178624
ID:
200178624

PubMed Full text in PMC Similar studies SRA Run Selector

3.

Illumina HiSeq 4000 (Mus musculus)

Organism:
Mus musculus
6635 Series
142643 Samples
Download data
Platform
Accession:
GPL21103
ID:
100021103

4.

TS_hyp_d2_RNA_rep2

Organism:
Mus musculus
Source name:
Extraembryonic stem cells
Platform:
GPL21103
Series:
GSE178624 GSE178628
Download data
Sample
Accession:
GSM5394636
ID:
305394636

SRA Run Selector

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db=gds|term=GSM5394636[Accession]|query=1|qty=2|blobid=MCID_67582db392c1a02ffd70d368|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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