GEO DataSets

(Submitter supplied) Midbrain dopamine (DA) neurons in the substantia nigra pars compacta (SNpc) project widely throughout the central nervous system, playing critical roles in voluntary movements, reward processing, and working memory. Many of these neurons are highly sensitive to neurodegeneration in Parkinson’s Disease (PD), and their loss correlates strongly with the pathognomonic symptoms. To characterize these populations molecularly, we developed a protocol to enrich and transcriptionally profile DA neuron nuclei from postmortem human SNpc of both PD patients and matched controls. more...

Organism:

Macaca mulatta; Homo sapiens; Tupaia belangeri; Rattus norvegicus

Type:

Expression profiling by high throughput sequencing

4 related Platforms

101 Samples

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