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Items: 3

1.

ADAM13 knockdown in Xenopus laevis cranial neural crest

(Submitter supplied) ADAMs are transmembrane metalloproteases that control cell behavior by cleaving both cell adhesion and signaling molecules. The cytoplasmic domain of ADAMs can regulate the proteolytic activity by controlling the subcellular localization and/or the activation of the protease domain. Here we show that the cytoplasmic domain of ADAM13 is cleaved and translocates into the nucleus. Preventing this translocation renders the protein incapable of promoting cranial neural crest (CNC) cell migration in vivo, without affecting its proteolytic activity. more...
Organism:
Xenopus laevis
Type:
Expression profiling by array
Platform:
GPL1318
9 Samples
Download data: CEL, TXT
Series
Accession:
GSE21517
ID:
200021517
2.

[Xenopus_laevis] Affymetrix Xenopus laevis Genome Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html The Affymetrix GeneChip Xenopus laevis Genome Array can be used to study gene expression of over 14,400 Xenopus laevis transcripts. Sequence information for this array was selected from the following public data sources: GenBank (release 135.0, April 2003), dbEST (June 2003), and UniGene (Build 36, June 2003). more...
Organism:
Xenopus laevis
4 DataSets
47 Series
414 Samples
Download data
Platform
Accession:
GPL1318
ID:
100001318
3.

CNC-MO13+C13-3

Organism:
Xenopus laevis
Source name:
Xenopus laevis CNC from stage 17 embryos injected with a morpholino to ADAM13 and a GFP-fusion protein containing the ADAM13 cytoplasmic domain.
Platform:
GPL1318
Series:
GSE21517
Download data: CEL
Sample
Accession:
GSM537527
ID:
300537527
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