GSM5287384[Accession] - GEO DataSets

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Items: 4

Select item 2001885791.

Ablation of cDC2 development by triple mutations within the Zeb2 enhancer

(Submitter supplied) The divergence of the common dendritic cell progenitor (CDP) into the conventional type 1 and type 2 dendritic cell (cDC1 and cDC2, respectively) lineages is poorly understood. Some transcription factors act in the commitment of already specified progenitors-such as BATF3, which stabilizes Irf8 autoactivation at the +32 kb Irf8 enhancer-but the mechanisms controlling the initial divergence of CDPs remain unknown. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL24247 GPL17021
21 Samples

Download data: BED, BEDGRAPH, TXT

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Accession:: GSE188579

ID:: 200188579

PubMed Full text in PMC Similar studies

Select item 2001741082.

Ablation of cDC2 specification by triple mutations in the Zeb2 enhancer [ChIP-Seq]

(Submitter supplied) The divergence of the common dendritic cell progenitor (CDP) into specified progenitors for the cDC1 and cDC2 dendritic cells subsets is poorly understood. Some transcription factors (TFs) act in commitment of already specified progenitors, such as Batf3 which stabilizes Irf8 autoactivation at the +32 kb Irf8 enhancer, but the mechanism of CDP divergence remains unknown. Here, we report the transcriptional basis of CDP divergence and describe the first requirements for pre-cDC2 specification. more...