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Items: 4

1.

The potential of epigenetic therapy to target the 3D epigenome in endocrine-resistant breast cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by array; Other; Methylation profiling by high throughput sequencing
4 related Platforms
88 Samples
Download data: BED, BW, HIC, IDAT, NARROWPEAK, TXT
Series
Accession:
GSE171074
ID:
200171074
2.

Epigenetic therapy suppresses tumour growth by rewiring ER-mediated long-range chromatin interactions in ER+ endocrine-resistant breast cancer [RNA-seq]

(Submitter supplied) Here we investigate the impact of epigenetic therapy with Decitabine in endocrine-resistant ER+ breast cancer by using patient-derived xenograft (PDX) models. Decitabine treatment restrained tumour growth, inhibited cell proliferation and resulted in significant loss of DNA methylation, particularly at enhancers and repetitive elements. Systematic integration of matched in situ Hi-C / PCHi-C, EPIC, RNA-seq and ChIP–seq datasets revealed widespread differences in epigenome regulation and enhancer-promoter communication with Decitabine. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
16 Samples
Download data: TXT
3.

Illumina NovaSeq 6000 (Homo sapiens)

Platform
Accession:
GPL24676
ID:
100024676
4.

HCI005 Decitabine 4_RNA-seq

Organism:
Homo sapiens
Source name:
HCI005 Decitabine tumour
Platform:
GPL24676
Series:
GSE171073 GSE171074
Download data
Sample
Accession:
GSM5218328
ID:
305218328
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Supplemental Content

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