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Items: 4

1.

Aberrant chromatin landscape upon loss of the H3.3 chaperone Daxx leads to Pu.1-mediated neutrophilia and inflammation [CUT&Tag]

(Submitter supplied) Defective silencing of retroviral elements has been linked to inflamm-aging, cancer and auto-immune diseases. However, the underlying mechanisms are only partially understood. Here, we implicate the histone H3.3 chaperone Daxx, a retrotransposable element (RTE) repressor inactivated in myeloid leukemia and other neoplasms, in protection from inflammatory disease. Loss of Daxx has profound effects on chromatin landscapes and histone marks of hematopoietic progenitors, leading to engagement of a Pu.1-dependent transcriptional program for myelopoiesis at the expense of B-cell differentiation. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL19057 GPL24247
62 Samples
Download data: BW, TXT
Series
Accession:
GSE168367
ID:
200168367
2.

Aberrant chromatin landscape upon loss of the H3.3 chaperone Daxx leads to Pu.1-mediated neutrophilia and inflammation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL18480 GPL24247 GPL19057
145 Samples
Download data
Series
Accession:
GSE119309
ID:
200119309
3.

Illumina NextSeq 500 (Mus musculus)

Platform
Accession:
GPL19057
ID:
100019057
4.

Daxx F/F Pu.1 F/F 24wpi H3K27ac 2

Organism:
Mus musculus
Source name:
Hematopoietic Stem/Progenitor Cell
Platform:
GPL19057
Series:
GSE119309 GSE168367
Download data
Sample
Accession:
GSM5137422
ID:
305137422
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Supplemental Content

db=gds|term=GSM5137422[Accession]|query=1|qty=2|blobid=MCID_662747e9e53bb618e1cd896c|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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