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Items: 3

1.

A fast Myh super enhancer dictates adult muscle fiber phenotype through competitive interactions with the fast Myh genes

(Submitter supplied) The contractile properties of adult myofibers are shaped by their Myosin heavy chain (MYH) isoform content. We identify by snATAC-seq a 42kb super-enhancer (SE) at the locus regrouping the fast Myh (fMyh) genes. By 4C-seq we show that active fMyh promoters interact with the SE by DNA looping, leading to the activation of a single promoter per nucleus. A rainbow mouse transgenic model of the locus including the SE recapitulates the endogenous spatio-temporal expression of adult fMyh genes. more...
Organism:
Mus musculus
Type:
Other
Platform:
GPL21626
11 Samples
Download data: BEDGRAPH, BW
Series
Accession:
GSE168074
ID:
200168074
2.

NextSeq 550 (Mus musculus)

Platform
Accession:
GPL21626
ID:
100021626
3.

4C_Muscle_Myh13

Organism:
Mus musculus
Source name:
Muscle
Platform:
GPL21626
Series:
GSE168074
Download data: BEDGRAPH, BW
Sample
Accession:
GSM5127881
ID:
305127881
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