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Items: 3

1.

TENT5 cytoplasmic non-canonical poly(A) polymerases regulate the innate immune response in animals

(Submitter supplied) Innate immunity, the first line of host defense against pathogens, is tightly regulated both transcriptionally and post-transcriptionally. Through global transcriptome and proteome analyses in Caenorhabditis elegans, we uncover a modulation of the expression of secreted innate immunity effector proteins by TENT5, one of a recently described family of cytoplasmic poly(A) polymerases. Direct RNA sequencing revealed that TENT-5 polyadenylates mRNAs with signal peptide-encoding sequences, that are translated at the endoplasmic reticulum. Loss of tent-5 function makes worms more susceptible to bacterial infection. Importantly, we demonstrate that the function of TENT-5 in innate immunity is evolutionarily conserved, as its orthologs, TENT5A and TENT5C are induced during macrophage activation and polyadenylate mRNAs, some of which are of genes orthologous to C. more...
Organism:
Caenorhabditis elegans; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL19757 GPL19057
18 Samples
Download data: TSV
Series
Accession:
GSE163549
ID:
200163549
2.

Illumina NextSeq 500 (Caenorhabditis elegans)

Organism:
Caenorhabditis elegans
210 Series
3371 Samples
Download data
Platform
Accession:
GPL19757
ID:
100019757
3.

HB_TENT-5_3

Organism:
Caenorhabditis elegans
Source name:
L4 worms
Platform:
GPL19757
Series:
GSE163549
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Sample
Accession:
GSM4981580
ID:
304981580
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db=gds|term=GSM4981580[Accession]|query=1|qty=3|blobid=MCID_666cb77c909a3d46ad9acfb0|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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