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Items: 4

1.

SUMOylation regulates the protein network and chromatin accessibility at glucocorticoid receptor-binding sites

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array
Platforms:
GPL10558 GPL11154 GPL18573
93 Samples
Download data: BEDGRAPH
Series
Accession:
GSE64373
ID:
200064373
2.

SUMOylation regulates the protein network and chromatin accessibility at glucocorticoid receptor-binding sites [sequencing]

(Submitter supplied) Glucocorticoid receptor (GR) is an essential transcription factor (TF), controlling metabolism, development and immune responses. SUMOylation regulates chromatin occupancy and target gene expression of GR in a locus-selective manner, but the mechanism of regulation has remained elusive. Here, we identify the protein network around chromatin-bound GR by using selective isolation of chromatin-associated proteins and show that the network is affected by receptor SUMOylation, with several nuclear receptor coregulators and chromatin modifiers preferring interaction with SUMOylation-deficient GR and proteins implicated in transcriptional repression preferring interaction with SUMOylation-competent GR. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platforms:
GPL11154 GPL18573
81 Samples
Download data: BEDGRAPH
3.

Illumina NextSeq 500 (Homo sapiens)

Platform
Accession:
GPL18573
ID:
100018573
4.

HEK293flpGR3KR_RNAseq_DMSO-EtOH_rep2

Organism:
Homo sapiens
Source name:
Isogenic HEK293 cells, SUMOylation-defective GR (GR3KR), vehicle, RNA
Platform:
GPL18573
Series:
GSE64301 GSE64373
Download data: BEDGRAPH
Sample
Accession:
GSM4955598
ID:
304955598
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Supplemental Content

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