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Items: 4

1.

Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below. Hematopoietic stem cells (HSCs) exhibit considerable cell-intrinsic changes with age. Here, we performed an integrated analysis of transcriptome and chromatin accessibility of aged HSCs and downstream progenitors. Alterations in chromatin accessibility preferentially took place in HSCs with aging, which gradually resolved with differentiation. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL18480
123 Samples
Download data: BW, CSV, H5, NARROWPEAK, TBI, TSV, TXT
Series
Accession:
GSE162662
ID:
200162662
2.

Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells (RNA-seq)

(Submitter supplied) Hematopoietic stem cells (HSCs) exhibit considerable cell-intrinsic changes with age. Here, we performed an integrated analysis of transcriptome and chromatin accessibility of aged HSCs and downstream progenitors. Alterations in chromatin accessibility preferentially took place in HSCs with aging, which gradually resolved with differentiation. Differentially open accessible regions (open DARs) in aged HSCs showed enrichment of binding motifs of the STAT, ATF, and CNC family transcription factors that are activated in response to external stresses, and most of them comprised active, primed , and inactive enhancers. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18480
32 Samples
Download data: TXT
Series
Accession:
GSE162607
ID:
200162607
3.

Illumina HiSeq 1500 (Mus musculus)

Platform
Accession:
GPL18480
ID:
100018480
4.

RNA-seq young MPP1 rep2

Organism:
Mus musculus
Source name:
10 week multipotent progenitor 1s
Platform:
GPL18480
Series:
GSE162607 GSE162662
Download data
Sample
Accession:
GSM4955246
ID:
304955246
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