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Items: 4

1.

Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below. Hematopoietic stem cells (HSCs) exhibit considerable cell-intrinsic changes with age. Here, we performed an integrated analysis of transcriptome and chromatin accessibility of aged HSCs and downstream progenitors. Alterations in chromatin accessibility preferentially took place in HSCs with aging, which gradually resolved with differentiation. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL18480
123 Samples
Download data: BW, CSV, H5, NARROWPEAK, TBI, TSV, TXT
Series
Accession:
GSE162662
ID:
200162662
2.

Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells(ATAC-seq)

(Submitter supplied) Hematopoietic stem cells (HSCs) exhibit considerable cell-intrinsic changes with age. Here, we performed an integrated analysis of transcriptome and chromatin accessibility of aged HSCs and downstream progenitors. Alterations in chromatin accessibility preferentially took place in HSCs with aging, which gradually resolved with differentiation. Differentially open accessible regions (open DARs) in aged HSCs showed enrichment of binding motifs of the STAT, ATF, and CNC family transcription factors that are activated in response to external stresses, and most of them comprised active, primed , and inactive enhancers. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL18480
36 Samples
Download data: BW, NARROWPEAK
Series
Accession:
GSE162551
ID:
200162551
3.

Illumina HiSeq 1500 (Mus musculus)

Platform
Accession:
GPL18480
ID:
100018480
4.

young MPP3 rep2

Organism:
Mus musculus
Source name:
10 week multipotent progenitor 3s
Platform:
GPL18480
Series:
GSE162551 GSE162662
Download data: BW, NARROWPEAK
Sample
Accession:
GSM4954101
ID:
304954101
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Supplemental Content

db=gds|term=GSM4954101[Accession]|query=1|qty=2|blobid=MCID_6670d9d2ce9c6e4cac322b51|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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