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Items: 4

1.

Nuclear m6A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos [ES cell RNA-seq]

(Submitter supplied) N6-methyladenosine (m6A) on chromosome-associated regulatory RNAs (carRNAs), including repeat RNAs, plays important roles in tuning the chromatin state and transcription, but the intrinsic mechanism remains unclear. Here, we report that YTHDC1 plays indispensable roles in the embryonic stem cell (ESC) self-renewal and differentiation potency, which highly depends on its m6A-binding ability. Ythdc1 is required for sufficient rRNA synthesis and repression of the 2-cell transcriptional program in ESCs, which recapitulates the transcriptome regulation by the LINE1 scaffold. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
21 Samples
Download data: FPKM_TRACKING
Series
Accession:
GSE157262
ID:
200157262

PubMed Full text in PMC Similar studies SRA Run Selector

2.

Nuclear m6A reader Ythdc1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL24247
54 Samples
Download data: BW, FPKM_TRACKING
Series
Accession:
GSE157268
ID:
200157268

3.

Illumina NovaSeq 6000 (Mus musculus)

Organism:
Mus musculus
13812 Series
688671 Samples
Download data
Platform
Accession:
GPL24247
ID:
100024247

4.

RNA_ESC_Ythdc1KO_3

Organism:
Mus musculus
Source name:
embryonic stem cells
Platform:
GPL24247
Series:
GSE157262 GSE157268
Download data: FPKM_TRACKING
Sample
Accession:
GSM4760326
ID:
304760326

SRA Run Selector

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db=gds|term=GSM4760326[Accession]|query=1|qty=2|blobid=MCID_6705e38a91df3b340a852af8|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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