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Items: 3

1.

Transcriptional profiling of striatum and cortex from a LacO-Q140 inducible mouse model of Huntington’s disease with early and late mutant HTT lowering

(Submitter supplied) Inducible mutant huntingtin mice were genetically engineered by introducing the lac operon sequence (LacO) into the Q140 promoter of the Q140 KI mice. LacO-140Q mice were then crossed to transgenic Lac repressor protein (LacIR) mice. LacIR occupies the LacO sequence in the promoter and thereby blocks transcription of Q140. Beta-galactoside analog isopropyl thiogalactoside (IPTG) binds to LacIR, which results in decreased affinity between the repressor and operator, thereby relieving repression. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
217 Samples
Download data: TXT
Series
Accession:
GSE156236
ID:
200156236
2.

Illumina NovaSeq 6000 (Mus musculus)

Platform
Accession:
GPL24247
ID:
100024247
3.

WT 6 months MOCK Striatum male mRNA rep5

Organism:
Mus musculus
Source name:
Right Striatum
Platform:
GPL24247
Series:
GSE156236
Download data
Sample
Accession:
GSM4727410
ID:
304727410
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