GSM4669074[Accession] - GEO DataSets

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Items: 4

Select item 2001464671.

The RNA m6A reader YTHDC1 silences retrotransposons and guards ES cell identity

(Submitter supplied) The RNA modification N6-methyladenosine (m6A) has critical roles in many biological processes. However, the function of m6A in the early phase of mammalian development remains poorly understood. Here we show that the m6A reader YT521-B homology-domain-containing protein 1 (YTHDC1) is required for the maintenance of mouse embryonic stem (ES) cells in an m6A-dependent manner, and that its deletion initiates cellular reprogramming to a 2C-like state. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Other

Platform:: GPL21273
100 Samples

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Accession:: GSE146467

ID:: 200146467

PubMed Similar studies

Select item 2001464662.

High throughput sequencing for YTHDC1 binding RNAs [RNA-seq]

(Submitter supplied) N6-methyladenoisne (m6A) plays critical roles in many biological processes. However, the function of m6A at the early phase of mammalian development remains poorly understood. Here we show that m6A reader Ythdc1 is required for the proliferation of mouse embryonic stem cells (mESCs) in an m6A-dependent manner and its deletion resets mESCs back to a 2C-like state.