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Items: 6

1.

DNA replication-timing boundaries separate stable chromosome domains with cell-type-specific functions

(Submitter supplied) Eukaryotic chromosomes replicate in a temporal order known as the replication-timing program. In mammals, replication timing is cell type-specific with at least half the genome switching replication timing during development, primarily in units of 400-800 kilobases ('replication domains;), whose positions are preserved in different cell types, conserved between species, and appear to confine long-range effects of chromosome rearrangements. more...
Organism:
Homo sapiens; Mus musculus
Type:
Other
25 related Platforms
993 Samples
Download data: BAM, BED, BIGWIG, BROADPEAK, NARROWPEAK, PAIR, TSV, TXT
Series
Accession:
GSE51334
ID:
200051334
2.

A comparative encyclopedia of DNA elements in the mouse genome

(Submitter supplied) The laboratory mouse shares the majority of its protein-coding genes with humans, making it the premier model organism in biomedical research, yet the two mammals differ in significant ways. To gain greater insights into both shared and species-specific transcriptional and cellular regulatory programs in the mouse, the Mouse ENCODE Consortium has mapped transcription, DNase I hypersensitivity, transcription factor binding, chromatin modifications and replication domains throughout the mouse genome in diverse cell and tissue types. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome variation profiling by genome tiling array; Genome binding/occupancy profiling by high throughput sequencing
8 related Platforms
588 Samples
Download data: BAM, BEDRNAELEMENTS, BIGWIG, BROADPEAK, NARROWPEAK, PAIR
Series
Accession:
GSE49847
ID:
200049847
3.

Genome-Wide Dynamics of Replication Timing Revealed by In Vitro Models of Mouse Embryogenesis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array; Genome variation profiling by genome tiling array
4 related Platforms
42 Samples
Download data: PAIR
Series
Accession:
GSE18019
ID:
200018019
4.

Replication Timing Reveal An Epigenetic Commitment To Differentiation Prior To Germ Layer Specification (WG_CGH, RT)

(Submitter supplied) Differentiation of mouse embryonic stem cells (mESCs) is accompanied by global changes in replication timing. To elucidate this reorganization process and explore its potential impact on mouse development, we constructed genome-wide replication-timing profiles of 15 independent mouse cell types representing nine different stages of early mouse development, including all three germ layers. Overall, 45% of the genome exhibits significant changes in replication timing between cell types, indicating that replication-timing regulation is more extensive than previously estimated from neural differentiation. more...
Organism:
Mus musculus
Type:
Genome variation profiling by genome tiling array
Platform:
GPL9156
22 Samples
Download data: PAIR
Series
Accession:
GSE17983
ID:
200017983
5.

FSU NimbleGen Mouse 385K Whole Genome Tiling

(Submitter supplied) Build: MM8, NCBI 36 native array description file: 2006-07-26_MM8_WG_CGH.ndf native array description file: 2006-07-26_MM8_WG_CGH.pos Protocol: NimbleGen
Organism:
Mus musculus
6 Series
26 Samples
Download data: NDF, POS
Platform
Accession:
GPL9156
ID:
100009156
6.

Replication timing of 46C NPC/ASd6

Organism:
Mus musculus
Source name:
Early-replicating DNA of 46C NPC/ASd6 (channel 1) Late-replicating DNA of 46C NPC/ASd6 (channel 2)
Platform:
GPL9156
Series:
GSE17983 GSE18019 GSE49847 GSE51334
Download data: PAIR
Sample
Accession:
GSM450283
ID:
300450283
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