GSM4486353[Accession] - GEO DataSets

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Items: 4

Select item 2001489431.

Discrete regulation of β-catenin-mediated transcription governs identity of intestinal epithelial stem cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL17021 GPL24247 GPL19057
25 Samples

Download data: NARROWPEAK, TXT

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Accession:: GSE148943

ID:: 200148943

PubMed Full text in PMC Similar studies

Select item 2001489402.

Discrete regulation of β-catenin-mediated transcription governs identity of intestinal epithelial stem cells [ATAC-Seq]

(Submitter supplied) The homeostasis of the gut epithelium relies upon continuous renewal and proliferation of crypt-resident intestinal epithelial stem cells (IESCs). Wnt/β-catenin signaling is required for IESC maintenance, however, it remains unclear how this pathway selectively governs the identity and proliferative decisions of IESCs. Here, we demonstrate that C-terminally-recruited transcriptional co-factors of β-catenin act as all-or-nothing regulators of Wnt-target gene expression. more...