GSM4405400[Accession] - GEO DataSets

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Items: 4

Select item 2001467521.

CTCF is required to form regulatory and physical boundaries at limited sites in the Drosophila nervous system

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other

Platforms:: GPL17275 GPL21306 GPL23702
33 Samples

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Accession:: GSE146752

ID:: 200146752

PubMed Full text in PMC Similar studies

Select item 2001467502.

CTCF is required to form regulatory and physical boundaries at limited sites in the Drosophila nervous system [Hi-C]

(Submitter supplied) CCCTC-binding factor (CTCF) is a conserved protein able to block communication between regulatory elements and gene promoters in flies and mammals. Here, we studied CTCF function in the Drosophila central nervous system (CNS) in which we find CTCF plays a vital role. Hi-C experiments on dissected larval CNSs of wildtype controls and CTCF[0] mutants that completely lack CTCF revealed that CTCF forms hundreds of physical boundaries in fly chromosomes.