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Items: 4

1.

Key Super Enhancers Drive Tumor-Suppressing Transcription Feedback Programs in Mature B Cell Cancers

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Genome variation profiling by SNP array; Expression profiling by array
Platforms:
GPL6801 GPL11154 GPL16686
301 Samples
Download data: CEL, CHP, NARROWPEAK, TXT
Series
Accession:
GSE145848
ID:
200145848
2.

Key Super Enhancers Drive Tumor-Suppressing Transcription Feedback Programs in Mature B Cell Cancers (ChIP-seq, FAIRE-seq)

(Submitter supplied) Dynamic changes to the epigenome are essential regulators of B cell differentiation and, when perturbed, can lead to cancer. We compared three types of mature B cell lymphoma/leukemia (BCL) and normal lymphocytes to identify common and distinct epigenetic perturbations that promote oncogenesis. Purified malignant B cells from 52 patients (18 Follicular, 11 Diffuse Large B Cell, 23 Chronic Lymphocytic Lymphomas) and normal B cell subsets from 28 donor tonsils were subjected to chromatin immunoprecipitation and sequencing (ChIP-seq) for H3K4me1, H3K9/14ac, and H3K27ac; FAIRE-seq for open chromatin; RNA-seq; and genome copy number arrays. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL11154
204 Samples
Download data: NARROWPEAK, TXT
Series
Accession:
GSE145841
ID:
200145841
3.

Illumina HiSeq 2000 (Homo sapiens)

Platform
Accession:
GPL11154
ID:
100011154
4.

DL191_H3AC_ChIP

Organism:
Homo sapiens
Source name:
CD19+ B cells
Platform:
GPL11154
Series:
GSE145841 GSE145848
Download data: NARROWPEAK
Sample
Accession:
GSM4337244
ID:
304337244
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