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Items: 3

1.

Single-cell RNA-seq: INCB059872 in wild-type murine bone marrow

(Submitter supplied) INCB059872 is a selective irreversible inhibitor of Lysine-Specific Demethylase 1 (LSD1) that is in phase 1 clinical trials in hematopoietic malignancies. Mice treated with INCB059872 had reduced platelet counts within 4 days of treatment. Here, we used single-cell RNA-seq to study the effects of INCB059872 on hematopoietic progenitor populations within wild-type murine bone marrow. Our results showed that INCB059872 triggered accumulation of megakaryocyte early progenitor cells with gene expression hallmarks of stem cells, which may begin to explain the thrombocytopenia observed in patients treated with LSD1 inhibitors.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
9 Samples
Download data: TAR
Series
Accession:
GSE145279
ID:
200145279
2.

Illumina NovaSeq 6000 (Mus musculus)

Platform
Accession:
GPL24247
ID:
100024247
3.

single cells_Control C

Organism:
Mus musculus
Source name:
lineage-negative bone marrow
Platform:
GPL24247
Series:
GSE145279
Download data: TAR
Sample
Accession:
GSM4314101
ID:
304314101
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