GSM4310105[Accession] - GEO DataSets

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Items: 4

Select item 2001452441.

Erythrophagocytosis drives anti-inflammatory programming of liver macrophages

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL10333 GPL24247 GPL19057
49 Samples

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Series

Accession:: GSE145244

ID:: 200145244

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001452432.

Erythrophagocytosis drives anti-inflammatory programming of liver macrophages (Bulk RNA seq BMDMs)

(Submitter supplied) Under conditions of erythrolytic stress, which accompanies many disease states, macrophages play key roles in phagocytosing damaged RBCs and preventing the toxic effects of cell-free hemoglobin and heme to maintain homeostasis. Using a genetic mouse model of spherocytosis and single-cell RNA sequencing, we show that erythrolytic stress promotes expansion of a specific macrophage population in the liver (which we named “erythrophagocytes”) expressing high levels of Marco and Hmox1 and low levels of MHC class II related genes with an anti-inflammatory gene expression signature. more...