GSM4239972[Accession] - GEO DataSets

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Items: 4

Select item 2001432041.

p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL24247 GPL21103
31 Samples

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Series

Accession:: GSE143204

ID:: 200143204

PubMed Full text in PMC Similar studies

Select item 2001427722.

p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis

(Submitter supplied) The tumor suppressor p53 transcriptionally activates target genes to suppress cellular proliferation during stress. p53 has also been implicated in the repression of the proto-oncogene Myc, but the mechanism has remained unclear. Here, we identify Pvt1b, a p53-dependent isoform of the long noncoding RNA (lncRNA) Pvt1, expressed 50 Kb downstream of Myc, which becomes induced by DNA damage or oncogenic signaling and accumulates near its site of transcription. more...