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Items: 3

1.

Genome-wide in vivo CNS Screening Identifies Genes that Modify CNS Neuronal Survival and mHTT Toxicity

(Submitter supplied) Unbiased in vivo genome-wide genetic screening is a powerful approach to elucidate new molecular mechanisms, but such screening has not been possible to perform in the mammalian central nervous system (CNS). Here we report the results of the first genome-wide genetic screens in the CNS using both shRNA and CRISPR libraries. Our screens identify many classes of CNS neuronal essential genes, and demonstrate that CNS neurons are particularly sensitive not only to perturbations to synaptic processes, but also autophagy, proteostasis, mRNA processing, and mitochondrial function. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
20 Samples
Download data: TAR
Series
Accession:
GSE141856
ID:
200141856
2.

Illumina NovaSeq 6000 (Mus musculus)

Platform
Accession:
GPL24247
ID:
100024247
3.

Spiny projection neurons, R62Hemi_CtlOX, rep4

Organism:
Mus musculus
Source name:
Striatum
Platform:
GPL24247
Series:
GSE141856
Download data: TAR
Sample
Accession:
GSM4214758
ID:
304214758
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