GSM4204640[Accession] - GEO DataSets

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Items: 4

Select item 2001414881.

Variant PCGF1-PRC1 links PRC2 recruitment with induced transcriptional inactivation at target genes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL18480 GPL19057 GPL24247
183 Samples

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Accession:: GSE141488

ID:: 200141488

PubMed Full text in PMC Similar studies

Select item 2001414872.

Variant PCGF1-PRC1 links PRC2 recruitment with induced transcriptional inactivation at target genes [RNA-seq]

(Submitter supplied) Polycomb repressive complexes-1 and -2 (PRC1 and 2), silence developmental genes in spatiotemporally regulated manner during metazoan embryogenesis. How PcG proteins contribute to down-regulation of target genes upon differentiation, however, remains elusive. Here, by differentiating embryonic stem cells into embryoid bodies, we reveal a crucial role of a PCGF1 (Polycomb group RING finger protein 1)-containing variant PRC1 complex (PCGF1-PRC1) to facilitate induced down-regulation of a group of genes. more...