GSM4176067[Accession] - GEO DataSets

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Items: 4

Select item 2001406771.

Intra-Vk Cluster Recombination Shapes the Ig Kappa Locus Repertoire

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Other; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL16417 GPL15520 GPL21626
69 Samples

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Series

Accession:: GSE140677

ID:: 200140677

PubMed Full text in PMC Similar studies

Select item 2001406352.

Intra-Vk Cluster Recombination Shapes the Ig Kappa Locus Repertoire [END-seq]

(Submitter supplied) During V(D)J recombination RAG proteins introduce DNA double strand breaks (DSBs) adjacent to conserved recombination signal sequences (RSS) that contain either 12- or 23-nucleotide spacer regions. Coordinated cleavage following the “12/23” rule predicts that DSBs at variable (V) gene segments should not exceed the level of breakage at joining (J) segments, thereby ensuring that V regions do not engage in undesirable recombination events with one another. more...