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Items: 4

1.

Chromatin Hyperacetylation Impacts Chromosome Folding by Forming a Nuclear Subcompartment

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing; Other; Expression profiling by high throughput sequencing
4 related Platforms
101 Samples
Download data: BW, HIC
Series
Accession:
GSE133165
ID:
200133165
2.

Hi-C to Identify Interactions between Distant Genomic Loci due to BRD4-NUT-mediated Megadomain Formation

(Submitter supplied) Delineating how chromosomes fold at length scales beyond one megabase remains obscure relative to smaller-scale folding into TADs, loops, and nucleosomes. We find that rather than simply unfolding chromatin, histone hyperacetylation results in interactions between distant genomic loci separated by tens to hundreds of megabases, even in the absence of transcription. These hyperacetylated “megadomains” are formed by the BRD4-NUT fusion oncoprotein, interact both within and between chromosomes, and form a specific nuclear subcompartment that has elevated gene activity with respect to other subcompartments. more...
Organism:
Homo sapiens
Type:
Other
Platforms:
GPL24676 GPL20795 GPL15520
32 Samples
Download data: BED, BEDPE, BW, HIC
Series
Accession:
GSE133163
ID:
200133163
3.

Illumina MiSeq (Homo sapiens)

Platform
Accession:
GPL15520
ID:
100015520
4.

TC-797_input_replicate4 (HiC)

Organism:
Homo sapiens
Source name:
TC-797 cultured cells
Platform:
GPL15520
Series:
GSE133163 GSE133165
Download data
Sample
Accession:
GSM4134931
ID:
304134931
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