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Items: 3

1.

Selective Inhibitors of mTORC1 Activate 4EBP1 and Suppress Tumor Growth

(Submitter supplied) The clinical benefit of current mTOR inhibitors is limited, perhaps reflecting their intrinsic pharmacological profiles. Rapamycin analogs selectively inhibit mTORC1, but fail to suppress phosphorylation of the mTORC1 substrate 4EBP1, a translational repressor that is a key driver of oncogenic mTORC1 signaling. mTOR kinase active-site inhibitors fully suppress mTORC1 and phosphorylation of its substrates, but are active against mTORC2 and additional kinases, potentially contributing to tolerability limitations. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
50 Samples
Download data: TXT
2.

Illumina NovaSeq 6000 (Homo sapiens)

Platform
Accession:
GPL24676
ID:
100024676
3.

cyto_MLN0128_1A

Organism:
Homo sapiens
Source name:
MCF7 cells
Platform:
GPL24676
Series:
GSE138417
Download data: TXT
Sample
Accession:
GSM4107725
ID:
304107725
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Supplemental Content

db=gds|term=GSM4107725[Accession]|query=1|qty=2|blobid=MCID_661f1c78610dde48c44f590c|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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