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Items: 3

1.

Germline-Encoded Affinity for Cognate Antigen Enables Vaccine Amplification of a Human Broadly Neutralizing Response Against Influenza Virus

(Submitter supplied) Antibodies display antigen-binding loops comprised of a hypervariable CDRH3 and V gene-encoded CDRs, where the latter may harbor gene-endowed or ‘public’ targeting solutions. To test this, we generated transgenic mice containing human CDRH3 diversity but simultaneously constrained to individual human immunoglobulin VH genes, including IGHV1-69, which shows biased usage in human broadly neutralizing antibodies (bnAbs) targeting the hemagglutinin stalk of Group 1 influenza A viruses. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16417
1475 Samples
Download data: TXT
Series
Accession:
GSE135761
ID:
200135761
2.

Illumina MiSeq (Mus musculus)

Platform
Accession:
GPL16417
ID:
100016417
3.

BCR2__S0111_S111

Organism:
Mus musculus
Source name:
IGHV1-69_VH_Post Boost 1_Splenic B cells
Platform:
GPL16417
Series:
GSE135761
Download data
Sample
Accession:
GSM4027824
ID:
304027824
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db=gds|term=GSM4027824[Accession]|query=1|qty=2|blobid=MCID_667b4f438c5d4760e22f3214|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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