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Items: 4

1.

The Fundamental Role of Chromatin Loop Extrusion in Physiological V(D)J Recombination

(Submitter supplied) RAG endonuclease initiates IgH locus (Igh) V(D)J assembly in progenitor (pro)-B cells by joining Ds to JHs, before joining upstream VHs to DJH intermediates. In mouse pro-B cells, the CTCF-binding element (CBE)-anchored chromatin loop domain at the 3’end of Igh contains an internal sub-domain spanning the 5’CBE anchor (IGCR1), the DHs, and a RAG-bound recombination center (RC). The RC comprises JH-proximal D (DQ52), 4 JHs, and the intronic enhancer (“iEmu”). more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other; Genome variation profiling by high throughput sequencing
Platforms:
GPL17021 GPL21626 GPL16417
133 Samples
Download data: BED, BEDGRAPH, BEDPE, BW, HIC, TXT
Series
Accession:
GSE130224
ID:
200130224
2.

The Fundamental Role of Chromatin Loop Extrusion in Physiological V(D)J Recombination [3C-HTGTS]

(Submitter supplied) RAG endonuclease initiates IgH locus (Igh) V(D)J assembly in progenitor (pro)-B cells by joining Ds to JHs, before joining upstream VHs to DJH intermediates. In mouse pro-B cells, the CTCF-binding element (CBE)-anchored chromatin loop domain at the 3’end of Igh contains an internal sub-domain spanning the 5’CBE anchor (IGCR1), the DHs, and a RAG-bound recombination center (RC). The RC comprises JH-proximal D (DQ52), 4 JHs, and the intronic enhancer (“iEmu”). more...
Organism:
Mus musculus
Type:
Genome variation profiling by high throughput sequencing; Other
Platforms:
GPL21626 GPL16417
19 Samples
Download data: BEDGRAPH
Series
Accession:
GSE130214
ID:
200130214
3.

NextSeq 550 (Mus musculus)

Platform
Accession:
GPL21626
ID:
100021626
4.

dCas9Control_DpnII_iEmubait_rep2

Organism:
Mus musculus
Source name:
v-Abl transformed pro-B cell line
Platform:
GPL21626
Series:
GSE130214 GSE130224
Download data: BEDGRAPH
Sample
Accession:
GSM4026038
ID:
304026038
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Supplemental Content

db=gds|term=GSM4026038[Accession]|query=1|qty=2|blobid=MCID_66754117ccfbad768f9a73fe|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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