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Items: 3

1.

Nutrient regulation of the islet epigenome controls adaptive insulin secretion

(Submitter supplied) Adaptation of the islet β-cell insulin secretory response to changing insulin demand is critical for blood glucose homeostasis, yet the mechanisms underlying this adaptation are unknown. Here, we show that nutrient cues adapt insulin secretion by modulating chromatin state and transcription of genes regulating β-cell nutrient sensing and metabolism. Feeding stimulates histone acetylation at sites occupied by the chromatin-modifying enzyme Lsd1 in islets. more...
Organism:
Mus; Homo sapiens; Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
4 related Platforms
131 Samples
Download data: BEDGRAPH, DIFF, TXT
Series
Accession:
GSE134901
ID:
200134901
2.

Illumina HiSeq 4000 (Mus musculus)

Platform
Accession:
GPL21103
ID:
100021103
3.

mm_islets_LsdKOD7_RNAseq_B

Organism:
Mus musculus
Source name:
Pancreatic islets
Platform:
GPL21103
Series:
GSE134901
Download data
Sample
Accession:
GSM3978586
ID:
303978586
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db=gds|term=GSM3978586[Accession]|query=1|qty=4|blobid=MCID_66294079f436486715391d37|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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