GSM3972129[Accession] - GEO DataSets

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Items: 4

Select item 2001451941.

Single-cell epigenomics identifies a premetastatic regulatory program in lung adenocarcinoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL19057 GPL19415
10 Samples

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Series

Accession:: GSE145194

ID:: 200145194

Select item 2001348122.

Single-cell epigenomics identifies a premetastatic regulatory program in lung adenocarcinoma [sciATAC-seq]

(Submitter supplied) Here we use an improved single-cell chromatin profiling approach to determine epigenomic alterations across tumor progression in a mouse model of lung adenocarcinoma (LUAD). Specifically, we induced tumors by providing Adeno-SPC-Cre virus to mice intratracheally to induce tumors due to conditional expression the Kras G12D mutation and loss of p53 (termed the KPT model). Mice also expressed a tdTomato reporter allele allowing for the sorting of tumor cells in late-stages of tumor progression. more...