GSM3970406[Accession] - GEO DataSets

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Items: 4

Select item 2001347981.

Nucleosomes protect DNA from irradiation-induced double strand breaks in living cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing; Other

Platforms:: GPL19057 GPL18573
34 Samples

Download data: BED, BEDGRAPH, NARROWPEAK

Series

Accession:: GSE134798

ID:: 200134798

PubMed Full text in PMC Similar studies

Select item 2001347952.

Nucleosomes protect DNA from irradiation-induced double strand breaks in living cells (RNA-seq)

(Submitter supplied) The depletion of HMGB1 reduces the deposition of histones on naked DNA (Celona et al, 2011). in primary MEFs and yeast. We verified that the downmodulation of HMGB1 decreases histone level also in a model of murine mesothelioma. HMGB1 was KD in Murine Mesothelioma AB22 cells by the expression of a shRNA. Nucleosome positioning and occupancy were tested by ATAC-seq. Since a reduced amount of nucleosomes increase the cell sensitivity to gamma irradiatio, we tested the number and position of breaks using BLISS-seq.