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Items: 4

1.

Mutant Kras co-opts a progenitor-derived enhancer network to initiate pancreatic tumorigenesis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL21273 GPL16791
166 Samples
Download data: BW, TSV
Series
Accession:
GSE134236
ID:
200134236
2.

Mutant Kras co-opts a progenitor-derived enhancer network to initiate pancreatic tumorigenesis [ChIP-seq]

(Submitter supplied) Oncogenes are highly specific in the cells they can transform, although the molecular basis for this is poorly understood. Inflammation often promotes tumorigenesis, and in the pancreas it promotes cellular plasticity and accelerates Kras-driven neoplasia. We demonstrate that plasticity is coupled to the emergence of transient progenitor cells that are readily transformed by KrasG12D. The progenitor state is linked to coordinate upregulation of proliferation genes through chromatin opening at nearby lineage-specific enhancers. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL21273
33 Samples
Download data: BW
Series
Accession:
GSE134233
ID:
200134233
3.

HiSeq X Ten (Mus musculus)

Platform
Accession:
GPL21273
ID:
100021273
4.

Foxa2-KrasG12D_input_ChIP

Organism:
Mus musculus
Source name:
pancreatic adenocarcinoma
Platform:
GPL21273
Series:
GSE134233 GSE134236
Download data: BW
Sample
Accession:
GSM3940103
ID:
303940103
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Supplemental Content

db=gds|term=GSM3940103[Accession]|query=1|qty=3|blobid=MCID_667973a09041cd510c60f2ef|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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