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Items: 3

1.

Excessive O-GlcNAcylation causes heart failure and sudden death

(Submitter supplied) Heart failure is a leading cause of death worldwide, and failing heart muscle is marked by increased O-GlcNAcylation (OGN). It is unknown if excessive OGN contributes to cardiomyopathy and heart failure. OGN modifies serines and threonines, total OGN levels follow cellular nutrient and metabolic flux in addition to net activity of O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). We developed new transgenic mouse models with myocardial delimited over-expression of OGA and OGT, and found that OGT transgenic mice developed severe cardiomyopathy and premature death. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
24 Samples
Download data: XLSX
Series
Accession:
GSE134121
ID:
200134121
2.

Illumina NovaSeq 6000 (Mus musculus)

Platform
Accession:
GPL24247
ID:
100024247
3.

2138-2_heart_OGA_TG

Organism:
Mus musculus
Source name:
whole heart
Platform:
GPL24247
Series:
GSE134121
Download data
Sample
Accession:
GSM3937549
ID:
303937549
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db=gds|term=GSM3937549[Accession]|query=1|qty=2|blobid=MCID_661977996bc2bd5af491c390|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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