GSM3904591[Accession] - GEO DataSets

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Items: 4

Select item 2001332751.

Effects of transcription on genome - nuclear lamina interactions

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Other; Expression profiling by high throughput sequencing

Platforms:: GPL24676 GPL16791 GPL17021
174 Samples

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Accession:: GSE133275

ID:: 200133275

Select item 2001332722.

Effects of transcription on genome - nuclear lamina interactions: DamID-seq data

(Submitter supplied) In mammalian nuclei, transcriptionally active genomic regions tend to localize to the interior of the nucleus while inactive regions are often located at at the nuclear lamina. In this study we activated specific genes in lamina-associated domains by TALE-VP64 or CRISPRa-mediated activation. We also reduced transcription of individual genes by knockout of promoter/enhancer regions, or by insertion of a transcription termination sequence. more...