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Items: 3

1.

Removing a Double Bond from Ceramides Ameliorates Insulin Resistance and Hepatic Steatosis

(Submitter supplied) Ceramides contribute to the lipotoxicity that underlies diabetes, hepatic steatosis, and heart disease. By genetically engineering mice, we deleted the enzyme dihydroceramide desaturase-1 (DES1) which inserts a conserved double bond into the backbone of ceramides and other predominant sphingolipids. Ablation of DES1 from whole animals, or tissue-specific deletion in the liver, and/or adipose tissue resolved hepatic steatosis and insulin resistance in mice caused by leptin deficiency or obesogenic diets. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
16 Samples
Download data: TXT
Series
Accession:
GSE132056
ID:
200132056
2.

Illumina NovaSeq 6000 (Mus musculus)

Platform
Accession:
GPL24247
ID:
100024247
3.

186-NCD knockout

Organism:
Mus musculus
Source name:
Liver
Platform:
GPL24247
Series:
GSE132056
Download data
Sample
Accession:
GSM3840119
ID:
303840119
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db=gds|term=GSM3840119[Accession]|query=1|qty=2|blobid=MCID_67596dbcc087e36732a40ee1|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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