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Items: 3

1.

Myc is required for adaptive beta cell replication in young mice but is not sufficient in one year old mice fed with a high fat

(Submitter supplied) Purpose: To test the role of Myc in adaptive expansion of beta cells Methods: Islets were isolated from 8 week old or one year old male C57BL6 mice fed a standard or high fat diet. RNAseq and DNA mehtylseq was performed. Results: RNAseq showed that Myc target genes are upregulted in young, but not old mice after a short term high fat diet. DNA methylation analysis shows hypomethylation of cell cycle genes that are Myc targets in islets from young mice fed with a HFD. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing
Platforms:
GPL16417 GPL17021
29 Samples
Download data: TXT
Series
Accession:
GSE131941
ID:
200131941
2.

Illumina MiSeq (Mus musculus)

Platform
Accession:
GPL16417
ID:
100016417
3.

Old HFD 4 Methylseq

Organism:
Mus musculus
Source name:
Islets
Platform:
GPL16417
Series:
GSE131941
Download data: TXT
Sample
Accession:
GSM3831329
ID:
303831329
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