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Items: 3

1.

Activation of HOTTIP lncRNA perturbs HSC function leading to AML like disease

(Submitter supplied) We found that posterior HOXA-associated HOTTIP lncRNA is aberrantly activated in MLL-rearranged AMLs and required for the posterior HOXA chromatin structure and gene expression. Knock-out of HOTTIP attenuates leukemic progressions of the transplanted humanized AML mice by blocking posterior HOXA-associated AML gene expression programs while the dCas-VP160 mediated reactivation of HOTTIP restores HOXA locus chromatin structure and HOXA9-A13 gene expression in the CBS7/9 boundary depleted AML cells. more...
Organism:
Mus musculus; Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other
7 related Platforms
66 Samples
Download data: BED, TXT
Series
Accession:
GSE114981
ID:
200114981
2.

Illumina HiSeq 2500 (Homo sapiens)

Platform
Accession:
GPL16791
ID:
100016791
3.

HOTTIP-KO-MLL-ChIP-seq

Organism:
Homo sapiens
Source name:
MOLM13 leukemia cells
Platform:
GPL16791
Series:
GSE114981
Download data: BED
Sample
Accession:
GSM3735446
ID:
303735446
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db=gds|term=GSM3735446[Accession]|query=1|qty=3|blobid=MCID_662381984c13c13a0649c883|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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