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Items: 4

1.

The Fundamental Role of Chromatin Loop Extrusion in Physiological V(D)J Recombination

(Submitter supplied) RAG endonuclease initiates IgH locus (Igh) V(D)J assembly in progenitor (pro)-B cells by joining Ds to JHs, before joining upstream VHs to DJH intermediates. In mouse pro-B cells, the CTCF-binding element (CBE)-anchored chromatin loop domain at the 3’end of Igh contains an internal sub-domain spanning the 5’CBE anchor (IGCR1), the DHs, and a RAG-bound recombination center (RC). The RC comprises JH-proximal D (DQ52), 4 JHs, and the intronic enhancer (“iEmu”). more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other; Genome variation profiling by high throughput sequencing
Platforms:
GPL17021 GPL21626 GPL16417
133 Samples
Download data: BED, BEDGRAPH, BEDPE, BW, HIC, TXT
Series
Accession:
GSE130224
ID:
200130224
2.

The Fundamental Role of Chromatin Loop Extrusion in Physiological V(D)J Recombination [HTGTS V(D)J-seq]

(Submitter supplied) RAG endonuclease initiates IgH locus (Igh) V(D)J assembly in progenitor (pro)-B cells by joining Ds to JHs, before joining upstream VHs to DJH intermediates. In mouse pro-B cells, the CTCF-binding element (CBE)-anchored chromatin loop domain at the 3’end of Igh contains an internal sub-domain spanning the 5’CBE anchor (IGCR1), the DHs, and a RAG-bound recombination center (RC). The RC comprises JH-proximal D (DQ52), 4 JHs, and the intronic enhancer (“iEmu”). more...
Organism:
Mus musculus
Type:
Genome variation profiling by high throughput sequencing; Other
Platform:
GPL16417
76 Samples
Download data: TXT
Series
Accession:
GSE130216
ID:
200130216
3.

Illumina MiSeq (Mus musculus)

Platform
Accession:
GPL16417
ID:
100016417
4.

dCas9Control_DQ52RSSDNbait_rep1

Organism:
Mus musculus
Source name:
v-Abl transformed pro-B cell line
Platform:
GPL16417
Series:
GSE130216 GSE130224
Download data: TXT
Sample
Accession:
GSM3734022
ID:
303734022
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Supplemental Content

db=gds|term=GSM3734022[Accession]|query=1|qty=2|blobid=MCID_66752c278c5d4760e2b86051|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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