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Items: 4

1.

The Fundamental Role of Chromatin Loop Extrusion in Physiological V(D)J Recombination

(Submitter supplied) RAG endonuclease initiates IgH locus (Igh) V(D)J assembly in progenitor (pro)-B cells by joining Ds to JHs, before joining upstream VHs to DJH intermediates. In mouse pro-B cells, the CTCF-binding element (CBE)-anchored chromatin loop domain at the 3’end of Igh contains an internal sub-domain spanning the 5’CBE anchor (IGCR1), the DHs, and a RAG-bound recombination center (RC). The RC comprises JH-proximal D (DQ52), 4 JHs, and the intronic enhancer (“iEmu”). more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other; Genome variation profiling by high throughput sequencing
Platforms:
GPL17021 GPL21626 GPL16417
133 Samples
Download data: BED, BEDGRAPH, BEDPE, BW, HIC, TXT
Series
Accession:
GSE130224
ID:
200130224
2.

The Fundamental Role of Chromatin Loop Extrusion in Physiological V(D)J Recombination [ChIP-Seq]

(Submitter supplied) RAG endonuclease initiates IgH locus (Igh) V(D)J assembly in progenitor (pro)-B cells by joining Ds to JHs, before joining upstream VHs to DJH intermediates. In mouse pro-B cells, the CTCF-binding element (CBE)-anchored chromatin loop domain at the 3’end of Igh contains an internal sub-domain spanning the 5’CBE anchor (IGCR1), the DHs, and a RAG-bound recombination center (RC). The RC comprises JH-proximal D (DQ52), 4 JHs, and the intronic enhancer (“iEmu”). more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL17021 GPL21626
18 Samples
Download data: BED, BW
Series
Accession:
GSE130213
ID:
200130213
3.

NextSeq 550 (Mus musculus)

Platform
Accession:
GPL21626
ID:
100021626
4.

Nipbl_dCas9Control_rep1

Organism:
Mus musculus
Source name:
v-Abl transformed pro-B cell line
Platform:
GPL21626
Series:
GSE130213 GSE130224
Download data: BED, BW
Sample
Accession:
GSM3733939
ID:
303733939
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Supplemental Content

db=gds|term=GSM3733939[Accession]|query=1|qty=2|blobid=MCID_666bdb666e9d376f2323d509|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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